Study Findings from Qingdao University Broaden Understanding of Reperfusion Injury [Mitochondria-targetable Cyclometalated Iridium(Iii) Complex-based Luminescence Probe for Monitoring and Assessing Treatment Response of Ferroptosis-mediated...].

Předmět:	INTRACELLULAR space CELL anatomy TRANSITION metals VASCULAR diseases REPERFUSION injury LIPID peroxidation (Biology)
Zdroj:	Blood Weekly; 12/5/2024, p689-689, 1p
Abstrakt:	A study conducted at Qingdao University in the People's Republic of China focused on the role of ferroptosis in hepatic ischemia-reperfusion injury (HIRI) and the importance of monitoring mitochondrial hypochlorous acid (HClO) in assessing treatment strategies. Researchers developed a probe named NIR-Ir-HClO to visualize mitochondrial HClO fluxes in ferroptosis-mediated HIRI, allowing for accurate monitoring of mitochondrial HClO in living cells. The study concluded that the probe could serve as a reliable imaging tool for understanding the pathological mechanism of mitochondrial HClO in HIRI and developing new treatment strategies. [Extracted from the article]
Databáze:	Complementary Index
Externí odkaz:	Zobrazit plný text záznamu