Adult T-cell leukemia-lymphoma with neurolymphomatosis successfully controlled by valemetostat: a case report and review of literature.

Autor:	Toho, Masanori, Yasunaga, Megumi, Masuda, Yasutaka, Shimura, Arika, Masamoto, Yosuke, Sumi, Kensyo, Muramatsu, Kyosuke, Tsujita, Masahiko, Mitsuchi, Shuichiro, Yoshioka, Reo, Baba, Yusuke, Maekawa, Hiroki, Kimura, Tomohiko, Hamada, Masashi, Toda, Tatsushi, Kurokawa, Mineo
Předmět:	POSITRON emission tomography computed tomography CEREBROSPINAL fluid MAGNETIC resonance imaging CONTRAST-enhanced magnetic resonance imaging CANCER chemotherapy
Zdroj:	Leukemia & Lymphoma; Dec2024, Vol. 65 Issue 12, p1891-1895, 5p
Abstrakt:	The document discusses a case of a septuagenarian man with adult T-cell leukemia-lymphoma (ATL) and neurolymphomatosis, successfully managed with valemetostat. ATL is a rare and aggressive malignancy linked to HTLV-1, with neurological complications like CNS involvement and neurolymphomatosis. Treatment typically involves chemotherapy, but valemetostat, a novel inhibitor, showed promise in this case. The patient experienced improvements with valemetostat, but adverse reactions led to discontinuation and eventual demise. The study highlights the potential of valemetostat in treating ATL with neurological complications, emphasizing the need for further research in this area. [Extracted from the article]
Databáze:	Complementary Index
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