The impact of osteosarcopenia and its parameters on mortality of COVID-19 in-hospitalized older patients: the findings of BEH (Bushehr elderly health) program.

Autor: Shafiee, Gita, Marzban, Maryam, Abbaspour, Faeze, Darabi, Amirhossein, Balajam, Narges Zargar, Farhadi, Akram, Khaleghi, Mohammad Mehdi, Taherzadeh, Hossein, Fahimfar, Noushin, Falahatzadeh, Azar, Ghasemi, Negin, Ostovar, Afshin, Nabipour, Iraj, Larijani, Bagher, Heshmat, Ramin
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Zdroj: Journal of Diabetes & Metabolic Disorders; Dec2024, Vol. 23 Issue 2, p1919-1928, 10p
Abstrakt: Background: It has been documented that old age and chronic diseases are associated with poor prognosis and mortality among COVID-19 patients. Osteosarcopenia is a geriatric syndrome with a considerable prevalence which increases morbidity and mortality. This study investigated the relationship between COVID-19 mortality and osteosarcopenia and its parameters in-hospitalized patients in Bushehr, Iran. Methods: In this retrospective cohort study, participants of the Bushehr Elderly Health (BEH) program who were hospitalized due to COVID-19 between 1st March 2020 and 23rd September 2021 were assessed. Osteosarcopenia was considered as the presence of both osteopenia/osteoporosis and sarcopenia. We used the Cox proportional hazards model to identify the association between oteosarcopenia and the risk of COVID-mortality in 2442 person-days. Results: Among 4173 participants,297 patients were in-hospitalized due to COVID-19. We found that 80(26.94%) patients expired due to COVID-19 during the follow-up period. Osteosarcopenia and its parameters were more prevalent in patients who expired. The incidence rate of mortality among osteosarcopenic patients was 5.04(3.43– 7.40) per 100 person-days. In the Cox proportional hazards models, osteosarcopenia and its parameters increase the risk of COVID-mortality [Osteosarcopenia: HRadjusment:1.73(1.00-3.01), sarcopenia: HRadjusment:1.72(1.00-2.99), Osteoporosis: HRadjusment:2.67(1.53–4.67), Low muscle mass: HRadjusment:1.90(1.05–3.46), low muscle strength: HRadjusment:1.80(1.03–3.16), and low gait speed: HRadj:2.39(1.31–4.38). The ORs of ICU admission and use of invasive mechanical ventilation among osteosarcopenic patients and its parameters were higher than those without it. Conclusions: This study identified the impact of osteosarcopenia and its parameters on the mortality of in-hospitalized patients with COVID-19. Assessment of musculoskeletal disorders could help in early warning of older patients with severe COVID-19. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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