| Autor: |
Almahdy, Almahdy, Karima, Aisyah N., Nasif, Hansen, Oktomalioputri, Biomechy, Dillasamola, Dwisari |
| Předmět: |
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| Zdroj: |
Tropical Journal of Natural Product Research; Oct2024, Vol. 8 Issue 10, p8749-8772, 4p |
| Abstrakt: |
Memory is the most important component for humans to receive, store, process and replicate impressions, understanding or responses. Caffeine and taurine possess antioxidant activity with proven efficacy in improving memory. The study aims to evaluate the effect of the combination of caffeine and taurine on memory improvement compared to individual agents. This study used the Morris Water Maze method by looking at the latency time required for test animals to find the platform on the Morris Water Maze apparatus. The study used 21 male Wistar mice with 7 treatment groups of 3 mice each: normal control, inducer, caffeine 0.40 mg/20 g BW, taurine 0.14 mg/20 g BW, caffeine 0.40 mg/20 g BW + taurine 14 mg/20 g BW, caffeine 0.40 mg/20 g BW + taurine 7 mg/20 g BW, and caffeine 0.20 mg/20 g BW + taurine 14 mg/20 g BW. The test involved three stages: acquisition trial, probe trial 1, and probe trial 2. The results of the latency time for the test animals to reach the platform were analyzed using one-way ANOVA. The analysis showed no significant differences (p>0.05) between each test group. However, treatment group 3 showed the highest percentage of memory improvement. The study concluded that there were no significant differences between groups given a combination of caffeine and taurine with a single administration in improving memory and the combination of caffeine and taurine at 0.40 mg/20 g BW + taurine 14 mg/20 g BW (group 3) can significantly improve memory in male mice. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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