Genome Analysis of Fur Color in Sable (Martes zibellina L.), the Search for Mutations Determining the Absence of Pigmentation (Albino).

Autor: Filimonov, P. A., Manakhov, A. D., Mitina, M. Y., Onokhov, A. A., Chernova, I. E., Maksimova, L. V., Kashtanov, S. N., Rogaev, E. I.
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Zdroj: Russian Journal of Genetics; Nov2024, Vol. 60 Issue 11, p1584-1587, 4p
Abstrakt: In domesticated sable population, after almost 100 years of selective breeding, individuals with colored fur began to be recorded. In particular, in the offspring of a pair of sables with black coat color, a puppy with pastel coat color was identified. In the TYRP1 gene that determines this sable coat color, single nucleotide insertion was determined, and the trait inheritance mode was recessive. In 2022, in this population, puppies with white coat color were born simultaneously to the representatives of two sable lines. In most mammalian species, albinism is caused by the mutations in the TYR gene, which encodes the tyrosinase enzyme. In the present study, the sable TYR gene was analyzed as a functional candidate gene for albinism. Sequence analysis of the TYR gene coding region and splicing sites did not reveal any differences of white sables from standard colored sables, which suggested that the studied phenotype was caused by genetic variants in other genes. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index