Quality of care for secondary cardiovascular disease prevention in 2009-2017: population-wide cohort study of antiplatelet therapy use in Scotland.
| Autor: | Thalmann, Inna, Preiss, David, Schlackow, Iryna, Gray, Alastair, Mihaylova, Borislava |
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| Předmět: |
ARTERIOSCLEROSIS prevention
CLINICAL drug trials CARDIOVASCULAR disease prevention PATIENT compliance RISK assessment NATIONAL health services MYOCARDIAL infarction COMBINATION drug therapy CARDIOVASCULAR diseases MEDICAL quality control RESEARCH funding ARTERIOSCLEROSIS TERMINATION of treatment MULTIPLE regression analysis PERIPHERAL vascular diseases HOSPITAL care RETROSPECTIVE studies DESCRIPTIVE statistics MULTIVARIATE analysis LONGITUDINAL method ODDS ratio MEDICAL records ACQUISITION of data ISCHEMIC stroke PLATELET aggregation inhibitors SOCIODEMOGRAPHIC factors CONFIDENCE intervals COMPARATIVE studies PROPORTIONAL hazards models |
| Zdroj: | BMJ Quality & Safety; Nov2024, Vol. 33 Issue 11, p716-725, 10p |
| Abstrakt: | Background Antiplatelet therapy (APT) can substantially reduce the risk of further vascular events in individuals with established atherosclerotic cardiovascular disease (ASCVD). However, knowledge regarding the extent and determinants of APT use is limited. Objectives Estimate the extent and identify patient groups at risk of suboptimal APT use at different stages of the treatment pathway. Methods Retrospective cohort study using linked NHS Scotland administrative data of all adults hospitalised for an acute ASCVD event (n=150 728) from 2009 to 2017. Proportions of patients initiating, adhering to, discontinuing and re-initiating APT were calculated overall and separately for myocardial infarction (MI), ischaemic stroke and peripheral arterial disease (PAD). Multivariable logistic regression and Cox proportional hazards models were used to assess the contribution of patient characteristics in initiating and discontinuing APT. Results Of patients hospitalised with ASCVD, 84% initiated APT: 94% following an MI, 83% following an ischaemic stroke and 68% following a PAD event. Characteristics associated with lower odds of initiation included female sex (22% less likely than men), age below 50 years or above 70 years (aged <50 years 26% less likely, and aged 70-79, 80-89 and ≥90 years 21%, 39% and 51% less likely, respectively, than those aged 60-69 years) and history of mental health-related hospitalisation (45% less likely). Of all APT-treated individuals, 22% discontinued treatment. Characteristics associated with discontinuation were similar to those related to non-initiation. Conclusions APT use remains suboptimal for the secondary prevention of ASCVD, particularly among women and older patients, and following ischaemic stroke and PAD hospitalisations. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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