| Autor: |
Tavares, Juliete, Oliveira, Alfaete Vieira, de Souza Nascimento, Tyciane, Gomes, Jessica Maria Pessoa, Parente, Ana Caroline Barros, Bezerra, Jessica Rabelo, da Costa, Mac Dionys Rodrigues, de Aguiar, Mayara Sandrielly Soares, Sampaio, Tiago Lima, Lima, Francisco Arnaldo Viana, de Barros Viana, Glauce Socorro, de Andrade, Geanne Matos |
| Zdroj: |
Metabolic Brain Disease; Jan2025, Vol. 40 Issue 1, p1-17, 17p |
| Abstrakt: |
Alzheimer’s disease (AD) is a progressive neurodegenerative disease that causes gradual memory loss and cognitive impairment. Intracerebroventricular injections of streptozotocin (ICV-STZ) have been used as an experimental model of sporadic Alzheimer’s disease (SAD) because they produce deficits in brain insulin signaling, oxidative stress, neuroinflammation, and neurodegeneration, resulting in cognitive decline and memory impairment. Spirulina platensis (SPI) is a nutraceutical with anti-inflammatory, antioxidant, and neuroprotective properties. The objective of this work was to study the effects of SPI on cognitive deficits and neuronal damage in mice submitted to the experimental model of SAD induced by ICV-STZ. Male Swiss mice (25–35 g) received ICV-STZ (3 mg/Kg) bilaterally on days 1 and 3, SPI (50 and 100 mg/Kg, o.p.) or vehicle (saline) was administered 2 h after the second surgery, and once a day for 16 days. SPI treatment prevented working, episodic, spatial, and aversive memory deficits. Locomotor activity was not altered. ICV-STZ caused an increase in MDA, nitrite, and superoxide anion, while decreasing GSH. SPI treatment protected against GSH increase in the prefrontal cortex and hippocampus, and inhibited AChE activity in the prefrontal cortex. SPI prevented astrogliosis and microgliosis induced by ICV-STZ. These findings highlight the therapeutic potential of SPI for the treatment of SAD, indicating that its neuroprotective action is linked to antioxidant, anti-inflammatory, and AChE inhibitory activity. SPI- spirulina; ICV-STZ: Intracerebroventricular injections of streptozotocin; SPI: Spirulina; AChE: Acetylcholinesterase; GFAP:Glial fibrillary acidic protein. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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