| Autor: |
Taeseung Lee, Sunghoon Chang, Yongsoo Song, Junyeol Kim, Jinho Choi, Inrae Cho, Sanghyub Lee, Jikon Ryu, Woohyun Paik |
| Předmět: |
|
| Zdroj: |
Gut & Liver; 2024 Supplement, Vol. 18, p131-131, 1/4p |
| Abstrakt: |
Background/Aims Bacteria are present in pancreatic tissues and may affect tumor growth and immune responses in pancreatic cancer, with higher bacterial diversity correlating with better immune infiltration and prognosis. Meanwhile, anaerobes are associated with poor prognosis in pancreatic cancer. This study investigates the role of anti-anaerobe antibiotics in pancreatic cancer outcomes. Methods We retrospectively reviewed patients aged ≥18 years with pathologically confirmed pancreatic cancer from Seoul National University Hospital between January 2011 and January 2023. We investigated progression-free survival and overall survival according to the administration of metronidazole. Results Among pancreatic cancer patients undergoing palliative chemotherapy, there was no significant difference in progression-free survival [median, 7 months (6 – 8) vs. 7 months (6 – 8), p=0.561] and overall survival [median, 11 months (10 – 12) vs. 12 months (11 – 14), p=0.612] when comparing those who had never taken metronidazole with those who had taken it at least once. Conclusion It was found that metronidazole exposure may not affect the outcome of pancreatic cancer patients in a palliative setting. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
