| Autor: |
Gaynullina, D. K., Tarasova, O. S., Shvetsova, A. A. |
| Zdroj: |
Moscow University Biological Sciences Bulletin; 2024 Suppl 1, Vol. 79, pS49-S58, 10p |
| Abstrakt: |
Growth of the body in early postnatal ontogenesis is associated with changes in the functioning of many systems, including the cardiovascular system. The circulatory system of newborns is characterized by numerous structural and functional features, which are manifested at the systemic level in significantly lower arterial pressure. This review considers the differences in the mechanisms regulating vascular smooth muscle cell contraction in early postnatal ontogenesis and in adulthood, including age-related changes in the functioning of ion channels, the activity of which affects the level of membrane potential and intracellular concentration of calcium ions as well as changes in the calcium sensitivity of the contractile apparatus. The final section of the review discusses the relationship between the mechanisms regulating contraction and differentiation of vascular smooth muscle cells during their maturation. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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