| Abstrakt: |
The present study investigates the efficacy of matcha green tea in mitigating genotoxic damage and oxidative stress induced by gamma radiation exposure through modulation of the P38/MAPK pathway and ROS generation in bone marrow. Twenty-four rats were divided into four groups, each consisting of six animals of similar weight. The Control group (Group I) received 1 ml of normal saline orally per day for two weeks. The Radiation group (Group II) received the same saline regimen for two weeks followed by exposure to a single 4 Gy gamma radiation dose. In contrast, the Matcha group (Group III) received 200 mg of matcha per kg of body weight orally per day for two weeks. Lastly, the Matcha/Radiation group (Group IV) received the matcha regimen for two weeks before being exposed to the 4 Gy gamma radiation dose. Assessment of the P38/MAPK pathway, including levels of p38, protein thiol, and TAC, as well as oxidative stress parameters such as MDA and ROS, alongside comet assay analysis, was conducted to elucidate the protective effects of matcha green tea against bone marrow damage resulting from gamma radiation exposure. Exposure to gamma radiation led to increased levels of ROS, MDA, P38 protein, protein thiol, and DNA damage (as shown by the comet assay), along with a notable decrease in TAC levels, indicating damage to the bone marrow. However, administration of matcha green tea demonstrated significant improvements in these parameters, highlighting its potential as an antigenotoxic and antioxidant therapy against the damaging effects of gamma radiation. [ABSTRACT FROM AUTHOR] |
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