| Autor: |
de Oliveira, Joyce C., Abreu, Breno U., Paz, Esther R. S., Almeida, Renata G., Honorato, João, Souza, Cauê P., Fantuzzi, Felipe, Ramos, Victor F. S., Menna‐Barreto, Rubem F. S., Araujo, Maria H., Jardim, Guilherme A. M., da Silva Júnior, Eufrânio N. |
| Předmět: |
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| Zdroj: |
Chemistry - An Asian Journal; 11/18/2024, Vol. 19 Issue 22, p1-7, 7p |
| Abstrakt: |
Herein, we describe the Ru‐catalyzed C−H alkenylation of 1,4‐naphthoquinones (1,4‐NQs), resulting in 1,4‐naphthoquinoidal/SuFEx hybrids with moderate to good yields. This method provides a novel route for direct access to ethenesulfonyl‐fluorinated quinone structures. We conducted mechanistic studies to gain an in‐depth understanding of the elementary steps of the reaction. Additionally, we evaluated the prototypes against trypomastigote forms of T. cruzi, leading to the identification of compounds with potent trypanocidal activity. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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