| Autor: |
Li, Yuanyuan, Jiang, Tao, Mao, Jianfeng, Xu, Fangyi, Zhang, Rong, Yan, Jing, Cai, Jiachang, Xie, Yanjun |
| Předmět: |
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| Zdroj: |
Frontiers in Microbiology; 2024, p1-9, 9p |
| Abstrakt: |
Linezolid-resistant enterococci have increased in recent years due to the worldwide spread of acquired resistance genes (cfr , optrA , and poxtA) in clinical, animal, and environmental settings. This study investigated the carriage of optrA -positive enterococci among patients in the anorectal surgery ward in Hangzhou, China, and characterized the genetic context of optrA. A total of 173 wound secretion samples were obtained to screen optrA -positive enterococci. Of the 173 samples, 15 (8.67%) were positive for optrA , including 12 Enterococcus faecalis , two E. faecium , and one E. hirae. Multilocus sequence type analysis revealed that 12 optrA -positive E. faecalis isolates belonged to eight different sequence types (STs), of which ST16 was the main type. Eight optrA variants were identified, whose optrA flanking regions with a fexA gene downstream were bounded by different mobile genetic elements. Furthermore, the optrA gene in 8 out of 15 optrA -positive enterococci could be successfully transferred through conjugation. The findings revealed a high carriage rate of optrA in enterococci from one anorectal surgery ward in China. The dissemination of optrA -positive enterococci isolates in clinical settings should be continually monitored. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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