| Autor: |
Powell, Alice, Lam, Ben C.P., Foxe, David, Close, Jacqueline C.T., Sachdev, Perminder S., Brodaty, Henry |
| Zdroj: |
International Psychogeriatrics; Oct2024, Vol. 36 Issue 10, p939-955, 17p |
| Abstrakt: |
Objectives: To investigate the frequency of exceptional cognition (cognitive super-aging) in Australian older adults using different published definitions, agreement between definitions, and the relationship of super-aging status with function, brain imaging markers, and incident dementia. Design: Three longitudinal cohort studies. Setting: Participants recruited from the electoral roll, Australian Twins Registry, and community advertisements. Participants: Older adults (aged 65–106) without dementia from the Sydney Memory and Ageing Study (n = 1037; median age 78), Older Australian Twins Study (n = 361; median age 68), and Sydney Centenarian Study (n = 217; median age 97). Measurements: Frequency of super-aging was assessed using nine super-aging definitions based on performance on neuropsychological testing. Levels of agreement between definitions were calculated, and associations between super-aging status for each definition and functioning (Bayer ADL score), structural brain imaging measures, and incident dementia were explored. Results: Frequency of super-aging varied between 2.9 and 43.4 percent with more stringent definitions associated with lower frequency. Agreement between different criteria varied from poor (K = 0.04, AC1 =.24) to very good (K = 0.83, AC1 =.91) with better agreement between definitions using similar tests and cutoffs. Super-aging was associated with better functional performance (4.7–11%) and lower rates of incident dementia (hazard ratios 0.08–0.48) for most definitions. Super-aging status was associated with a lower burden of white matter hyperintensities (3.8–33.2%) for all definitions. Conclusions: The frequency of super-aging is strongly affected by the demographic and neuropsychological testing parameters used. Greater consistency in defining super-aging would enable better characterization of this exceptional minority. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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