| Autor: |
Pavan, Aline R., Smalley, Joshua P., Patel, Urvashi, Pytel, Wiktoria A., dos Santos, Jean Leandro, Cowley, Shaun M., Schwabe, John W. R., Hodgkinson, James T. |
| Předmět: |
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| Zdroj: |
Chemical Communications; 12/7/2024, Vol. 60 Issue 94, p13879-13882, 4p |
| Abstrakt: |
Histone deacetylase (HDAC) enzymes 1–3 exist in several corepressor complexes and are viable drug targets. To date, proteolysis targeting chimeras (PROTACs) designed to target HDAC1–3 typically exhibit the selective degradation of HDAC3. Herein, we report cereblon-recruiting PROTACs that degrade HDAC1 with selectivity over HDAC3. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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