| Autor: |
Willis, Mark D., Kreft, Karim L., Dancey, Bethan |
| Předmět: |
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| Zdroj: |
Practical Neurology; Oct2024, Vol. 24 Issue 5, p1-8, 8p |
| Abstrakt: |
Oligoclonal bands (OCBs) represent the presence of intrathecal immunoglobulin G (IgG) as detected by isoelectric focusing and immunofixation. Cerebrospinal fluid (CSF) analysed alongside a paired serum sample gives five different immunofixation patterns. These are: type 1--the normal physiological state with no intrathecal IgG synthesis; type 2--evidence for intrathecal IgG synthesis, with CSF- restricted OCBs; type 3--evidence for intrathecal IgG synthesis, with CSF- restricted OCBs, but with additional, identical bands in the CSF and serum; type 4--absence of intrathecal IgG synthesis, but with identical OCBs in CSF and serum; and type 5--absence of intrathecal IgG synthesis, with a monoclonal band in CSF and serum. Analysis of these patterns can help to diagnose a range of neurological conditions, including multiple sclerosis. However, it is important to interpret OCB results alongside other CSF tests and their clinical context. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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