| Abstrakt: |
Gold nanostructure can be manufactured in many forms, such as spherical, sheets, and rods by using simple chemical method. Chemical analysis of gold sample nanostructure prepared in various shapes where high-purity gold nanostructure samples can be used to treat induced kidney failure diseases in mice. Due to the kidneys' need for large amounts of oxygen to perform their functions, as their cells are considered one of the body cells most sensitive to lack of blood supply (oxygen, nutrition), so the renal capillaries secrete the hormone Erythropiotein, which activates the marrow bone cells, which helps to speed up their reproduction and its maturation, producing more RBCs, and by secreting the hormone erythropoietin, and the subsequent increase in the number of red blood cells (the main transporter of oxygen from the lungs to the various tissues of the body). It fully fulfills its needs, and this comes by reaching the normal range of red blood cells and hemoglobin count. Kidney function was evaluated by estimating the level of urea, creatinine and GFR, and by detecting anemia through estimating the levels of EPO hormone and hemoglobin, in addition to other tests affected by chronic kidney failure. The results obtained from measurements of mice blood and compared with the results of normal mice showed a significant increase (p < 0.01) in the level of urea and creatinine in the blood. In addition, an insignificant decrease (p > 0.05) in serum magnesium level in mice following oral administration of adenine at a dose = 2 ml/kg and concentration = 100 mg/ml for 60 days. Section in the kidney of infected animals under the treatment of [6]-gingerol + Au NPs, [6]-gingerol + Au NSs and [6]-gingerol + Au NRs at a dose = 2 ml/kg and concentration = 50 mg/ml orally shows no clear lesions in some animals. [ABSTRACT FROM AUTHOR] |
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