Autor: |
Fujiwara, Yasuhiro, Eitoku, Shoma, Sakae, Nobutaka, Izumi, Takahisa, Kumazoe, Hiroyuki, Kitajima, Mika |
Zdroj: |
Radiological Physics & Technology; Dec2024, Vol. 17 Issue 4, p869-877, 9p |
Abstrakt: |
In a 0.3 T permanent-magnet magnetic resonance imaging (MRI) system, quantifying myelin content is challenging owing to long imaging times and low signal-to-noise ratio. macromolecular proton fraction (MPF) offers a quantitative assessment of myelin in the nervous system. We aimed to demonstrate the practical feasibility of MPF mapping in the brain using a 0.3 T MRI. Both 0.3 T and 3.0 T MRI systems were used. The MPF-mapping protocol used a standard 3D fast spoiled gradient-echo sequence based on the single-point reference method. Proton density, T1, and magnetization transfer-weighted images were obtained from a protein phantom at 0.3 T and 3.0 T to calculate MPF maps. MPF was measured in all phantom sections to assess its relationship to protein concentration. We acquired MPF maps for 16 and 8 healthy individuals at 0.3 T and 3.0 T, respectively, measuring MPF in nine brain tissues. Differences in MPF between 0.3 T and 3.0 T, and between 0.3 T and previously reported MPF at 0.5 T, were investigated. Pearson's correlation coefficient between protein concentration and MPF at 0.3 T and 3.0 T was 0.92 and 0.90, respectively. The 0.3 T MPF of brain tissue strongly correlated with 3.0 T MPF and literature values measured at 0.5 T. The absolute mean differences in MPF between 0.3 T and 0.5 T were 0.42% and 1.70% in white and gray matter, respectively. Single-point MPF mapping using 0.3 T permanent-magnet MRI can effectively assess myelin content in neural tissue. [ABSTRACT FROM AUTHOR] |
Databáze: |
Complementary Index |
Externí odkaz: |
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