| Abstrakt: |
Aim: The objective of this study is to explore the association between inflammation and the severity of hypertension by analyzing inflammation biomarkers, such as CRP, IL-1, proBNP, leptin, and PTX-3 levels, in children with obesity-related hypertension. Material and Methods: The study included 30 children (20 girls, 10 boys) with obesity-related hypertension and 30 healthy children (22 girls, 8 boys) as controls. Clinical and demographic data were collected for all participants. Echocardiographic measurements of left ventricular systolic and diastolic diameters, volumes, and wall thicknesses were taken and adjusted for body surface area. After echocardiographic evaluation, blood samples (10 cc) were drawn from both groups to measure IL-1, CRP, leptin, proBNP, and PTX-3 levels. Results: The patient group had significantly higher systolic and diastolic blood pressure, height, weight, and body mass index compared to the control group. Echocardiographic assessments revealed significantly increased interventricular diastolic diameter (IVSd), left ventricular diastolic diameter (LVIDd), left ventricular posterior wall diastolic diameter (LVPWd), interventricular systolic diameter (IVSs), and left ventricular systolic diameter (LVIDs) in the patient group. Leptin and CRP levels were notably higher in the obesity group. In healthy children, there was a moderate positive correlation between leptin and systolic blood pressure. A moderate negative correlation was observed between proBNP and systolic blood pressure, and a weak positive correlation between leptin and diastolic blood pressure was noted in the obesity group. Leptin, blood pressure, height, weight, body mass index, and cardiac dimensions were significantly elevated in obese patients requiring anti-hypertensive treatment. Conclusion: Inflammatory markers may be crucial for early diagnosis of obesityrelated hypertension, guiding the development of therapeutic approaches to reduce target organ damage. Elevated inflammation markers in obese patients may indicate the severity of hypertension, aiding in organ damage prevention through lifestyle changes. [ABSTRACT FROM AUTHOR] |
