| Abstrakt: |
Ebola virus (EBOV), a member of the Filoviridae family, causes EBOV disease (EVD), a highly fatal and neglected tropical disease (NTD). Despite its severity, treatment options remain limited. While therapies such as monoclonal antibodies have shown some efficacy, they are insufficient to fully control the virus’s spread. Given the urgent need for novel treatments, antiviral peptides (AVPs), a type of antimicrobial peptides (AMPs), are emerging as promising alternatives due to their high selectivity, specificity, and low toxicity. However, there is no dedicated resource for AVPs against EBOV i.e., anti-Ebola peptides (AEPs). To address this gap, we have developed the Anti-Ebola Peptide Database (AEPDB), the first comprehensive database specifically for AEPs. AEPDB compiles 69 AEPs (67 unique) targeting multiple EBOV strains, sourced from literatures. The resource includes detailed information on peptide sequences, target EBOV strains, biological targets, mechanisms of action, and validation status, with cross-references to PubMed, UniProt, and PDB databases. We have designed AEPDB with an intuitive user interface (UI), offering basic, advanced, and list-based search options, detailed browsing, and data exports in various formats. AEPDB is a crucial resource for advancing research into EBOV therapeutics, supporting the development of new drugs to combat this deadly virus. AEPDB is freely accessible via any web browser at the URL: . [ABSTRACT FROM AUTHOR] |
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