| Abstrakt: |
Doxorubicin, a widely used chemotherapeutic agent, is effective against various cancers but is limited by severe hepatotoxicity due to oxidative stress and mitochondrial dysfunction. This study investigates the hepatoprotective effects of Premna integrifolia aqueous root extract on doxorubicin-induced liver damage in Wistar albino rats. Rats were divided into four groups: a control group, a doxorubicin-treated group, and two groups pre-treated with Premna integrifolia extract (200 mg/kg and 400 mg/kg). Biochemical markers (ALT, AST, ALP, bilirubin), oxidative stress markers (MDA, SOD, GSH), and histopathological parameters were analyzed. The results indicate that doxorubicin significantly elevated liver enzyme levels and oxidative stress markers, while pretreatment with Premna integrifolia significantly reduced these markers in a dose-dependent manner. The 400 mg/kg dose demonstrated a stronger hepatoprotective effect, restoring near-normal liver function and architecture. Histopathological evaluation confirmed reduced necrosis, Kupffer cell activation, and central vein dilation. The study concludes that Premna integrifolia possesses potent antioxidant and hepatoprotective properties, potentially offering a natural remedy for drug-induced hepatotoxicity. Further research should investigate its molecular mechanisms and clinical applications. [ABSTRACT FROM AUTHOR] |
