| Abstrakt: |
Introduction: Wound healing is a complex biological process composed of interrelated and overlapping phases: inflammation, migration, proliferation, and maturation. In severe wounds, such as large skin injuries, second or third-degree burns, or diabetes foot ulcers, wound healing is a slow process and rarely leads to the complete restoration of tissue function. Hydrogels are threedimensional polymeric networks that can swell in aqueous environment/biological fluids by absorbing the wound exudates while preventing wound dehydration. Aim: The aim of the study is to explore the development of a photo-crosslinked hydrogel incorporated with two potent natural compounds, curcumin and rutin and its efficacy in promoting wound healing. Materials and methods: Formation of hydrogel incorporated in correct proportions of curcumin and rutin was done. 10% gelatin was added and mixed with ethylene glycol to form gelatin methacrylate. 0.5 % of carrageenan was used. Rutin and curcumin in optimized concentration and 1:1 ratio stock sol. was used. It was then placed in 6 wells for room temp (30 minutes - 1 hour). Potassium chloride (KCl) was added for chemical cross linking, and it was then frozen at 80 degrees C and was lyophilized. Results: The results showed high ability of antimicrobial activity, Antioxidant activity, Compatibility and Anti-inflammatory properties for the photo-crosslinked hydrogel incorporated with curcumin and rutin. Conclusion: It can be concluded from our study that the development of a photo-crosslinked hydrogel incorporated with curcumin and rutin represents a promising approach for enhancing wound healing. [ABSTRACT FROM AUTHOR] |
