Aerobic Training and Ointment Effect on range of motion, von Willebrand factor, vascular endothelial factor and Femoral Artery Hemodynamics in Joint Contracture: A Rat Model.
| Autor: | Maimaiti, Palida, Shu, Jiaojiao, Miao, Tianyu, Keqike, Nuerbiya, Tuersun, Asiguli, Ruiqi Yang, Wang, Ningning |
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| Předmět: |
VASCULAR endothelial growth factors
CONTRACTURE (Pathology) EXERCISE physiology BIOLOGICAL models CHINESE medicine BLOOD coagulation disorders RESEARCH funding T-test (Statistics) OINTMENTS COMPUTED tomography ENZYME-linked immunosorbent assay HERBAL medicine HEMODYNAMICS TREATMENT effectiveness COLOR Doppler ultrasonography DESCRIPTIVE statistics JOINTS (Anatomy) RATS PRE-tests & post-tests EXPERIMENTAL design AEROBIC exercises GENETIC disorders ANIMAL experimentation ONE-way analysis of variance ANALYSIS of variance COMPARATIVE studies DATA analysis software RANGE of motion of joints FEMORAL artery EXTERNAL fixators HEALTH care teams THERAPEUTICS |
| Zdroj: | Biological Research for Nursing; Jan2025, Vol. 27 Issue 1, p17-27, 11p |
| Abstrakt: | Objective: Using a rat model, we investigated the effect of multidisciplinary rehabilitation, including aerobic training and ointment, on the ROM, vWF, VEGF content, and femoral artery hemodynamics in rats with joint contracture. Methods: A total of 44 Wistar rats were divided into the normal control group (NC, eight rats) and the experimental group (EG). A joint contracture model was established for the rats in the EG group by an external fixator. After fixator removal, 32 rats are further divided into the MC, SC, RE, and SR groups (n = 8). Before and after the 42 day intervention, the ROM, vWF, VEGF, PS, ED, and RI were measured using X-ray imaging, ELISA, and color Doppler ultrasound, respectively. Results: After fixator removal, ROM for EG group was lower than that of the NC group (p <.01). After the intervention, ROM for the SR, RE, and SC groups was improved. The ROM for the SR group reached a similar value for NC group. vWF and VEGF levels in SR group were lower than in the MC, SC, and RE groups (p <.05), and had a similar value to the NC groups. PS value for SR and RE groups was higher than the MC and SC groups. The RI value for SR group was higher than that of NC and MC groups. Conclusion: Multidisciplinary rehabilitation used in this study can treat joint contracture synergistically. It improves the ROM of the joint, reduces the content of vWF and VEGF, and improves the femoral artery hemodynamics. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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