Medical Comorbidities, Nutritional Markers, and Cardiovascular Risk Markers in Youth With ARFID.

Autor:	Burton‐Murray, Helen, Sella, Aluma Chovel, Gydus, Julia E., Atkins, Micaela, Palmer, Lilian P., Kuhnle, Megan C., Becker, Kendra R., Breithaupt, Lauren E., Brigham, Kathryn S., Aulinas, Anna, Staller, Kyle, Eddy, Kamryn T., Misra, Madhusmita, Micali, Nadia, Thomas, Jennifer J., Lawson, Elizabeth A.
Předmět:	ANALYSIS of triglycerides RISK assessment RESEARCH funding T-test (Statistics) INTERVIEWING KRUSKAL-Wallis Test FISHER exact test CARDIOVASCULAR diseases risk factors DESCRIPTIVE statistics CHI-squared test EATING disorders ODDS ratio CONFIDENCE intervals DATA analysis software BIOMARKERS NUTRITION COMORBIDITY C-reactive protein GASTROINTESTINAL diseases ADOLESCENCE
Zdroj:	International Journal of Eating Disorders; Nov2024, Vol. 57 Issue 11, p2167-2175, 9p
Abstrakt:	Objective: Avoidant/restrictive food intake disorder (ARFID) is common among populations with nutrition‐related medical conditions. Less is known about the medical comorbidity/complication frequencies in youth with ARFID. We evaluated the medical comorbidities and metabolic/nutritional markers among female and male youth with full/subthreshold ARFID across the weight spectrum compared with healthy controls (HC). Method: In youth with full/subthreshold ARFID (n = 100; 49% female) and HC (n = 58; 78% female), we assessed self‐reported medical comorbidities via clinician interview and explored abnormalities in metabolic (lipid panel and high‐sensitive C‐reactive protein [hs‐CRP]) and nutritional (25[OH] vitamin D, vitamin B12, and folate) markers. Results: Youth with ARFID, compared with HC, were over 10 times as likely to have self‐reported gastrointestinal conditions (37% vs. 3%; OR = 21.2; 95% CI = 6.2–112.1) and over two times as likely to have self‐reported immune‐mediated conditions (42% vs. 24%; OR = 2.3; 95% CI = 1.1–4.9). ARFID, compared with HC, had a four to five times higher frequency of elevated triglycerides (28% vs. 12%; OR = 4.0; 95% CI = 1.7–10.5) and hs‐CRP (17% vs. 4%; OR = 5.0; 95% CI = 1.4–27.0) levels. Discussion: Self‐reported gastrointestinal and certain immune comorbidities were common in ARFID, suggestive of possible bidirectional risk/maintenance factors. Elevated cardiovascular risk markers in ARFID may be a consequence of limited dietary variety marked by high carbohydrate and sugar intake. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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