| Autor: |
Yiliang Fu, Fei Li, Yun Zhu, Luci Huang, Qiuping Li, Hanwen Zhang, Lili Zhong, Hailin Zhang, Zheng-xiu Luo, Gen Lu, Jikui Deng, Lingfeng Cao, Ying Wu, Rong Jin, Lei Li, Lili Xu, Xiangpeng Chen, Zhengde Xie |
| Předmět: |
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| Zdroj: |
Virologica Sinica (16740769); Oct2024, Vol. 39 Issue 5, p727-736, 10p |
| Abstrakt: |
Respiratory syncytial virus (RSV) is a significant cause of acute lower respiratory tract infection (ALRTI) in children under five years of age. Between 2017 and 2021, 396 complete sequences of the RSV F gene were obtained from 500 RSV-positive throat swabs collected from ten hospitals across nine provinces in China. In addition, 151 sequences from China were sourced from GenBank and GISAID, making a total of 549 RSV F gene sequences subjected to analysis. Phylogenetic and genetic diversity analyses revealed that the RSV F genes circulating in China from 2017 to 2021 have remained relatively conserved, although some amino acids (AAs) have undergone changes. AA mutations with frequencies ≥ 10% were identified at six sites and the p27 region: V384I (site I), N276S (site II), R213S (site Ø), and K124N (p27) for RSV A; F45L (site I), M152I/L172Q/S173 L/I185V/K191R (site V), and R202Q/I206M/Q209R (site Ø) for RSV B. Comparing mutational frequencies in RSV-F before and after 2020 revealed minor changes for RSV A, while the K191R, I206M, and Q209R frequencies increased by over 10% in RSV B. Notably, the nirsevimab-resistant mutation, S211N in RSV B, increased in frequency from 0% to 1.15%. Both representative strains aligned with the predicted RSV-F structures of their respective prototypes exhibited similar conformations, with low root-mean-square deviation values. These results could provide foundational data from China for the development of RSV mAbs and vaccines. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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