Preclinical determination of wound-healing activity of halibut oil cream in rat model of burn wound.
| Autor: | Shukla, ST, Kaushik, Anu, Auti, Samiullah Allahbaksh, Kumar, Dinesh, Das, Supriya Kumar |
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| Předmět: |
CUTANEOUS therapeutics
WOUND healing BIOLOGICAL models HIGH performance liquid chromatography BURNS & scalds PROLINE DERMATOLOGIC agents DATA analysis LABORATORY animals OINTMENTS OMEGA-3 fatty acids VITAMIN A DESCRIPTIVE statistics RATS GAS chromatography ANIMAL experimentation HISTOLOGICAL techniques MOLECULAR structure ANTIOXIDANTS ONE-way analysis of variance ANALYSIS of variance STATISTICS WOUND care SILVER sulfadiazine COMPARATIVE studies VITAMIN D TOXICITY testing |
| Zdroj: | Journal of Asian Natural Products Research; Dec2024, Vol. 26 Issue 12, p1455-1474, 20p |
| Abstrakt: | This study investigated the effects of halibut oil cream, containing omega-3 fatty acids, vitamins A and D, and hydroxyproline, on burn wound healing in rats. Acute dermal toxicity tests confirmed its nontoxicity. Wistar rats were divided into five groups: a control, a positive control treated with silver sulfadiazine 1% (SSD), and three groups treated with 3%, 9%, and 27% halibut oil cream Formulation (HBOF). The SSD and HBOF groups showed significant healing improvements compared to the control. Histopathological analysis indicated increased collagen production in the HBOF groups, suggesting halibut oil cream's potential as a topical treatment for burn wounds. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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