| Abstrakt: |
Researchers from the University of Szeged in Hungary have developed a novel approach for preparing Ibuprofen-loaded inhalable cyclodextrin-based metal-organic frameworks (gCD-MOFs) using the freeze-drying method. By employing the Quality by Design (QbD) concept, they identified critical factors such as the molar ratio of Ibuprofen to gCD, incubation time, and percentage of organic solvent. The study demonstrated the successful formation of a gCD-MOF/IBU complex with optimal aerodynamic properties, leading to increased Ibuprofen solubility and a fast dissolution profile, highlighting the potential of these formulations as effective delivery systems for pulmonary intake. [Extracted from the article] |
