Affiliated Hospital of Guizhou Medical University Researchers Provide New Insights into Apoptosis (GRK2 Protein Mediates the ANRIL, a lncRNA, to Affect the Proliferation and Apoptosis of Kasumi-1 Cells).

Předmět:	PROLIFERATING cell nuclear antigen RNA-binding proteins BAX protein PROTEIN kinase B INHIBITION of cellular proliferation PROTEIN kinases
Zdroj:	Hematology Week; 11/11/2024, p352-352, 1p
Abstrakt:	Researchers at the Affiliated Hospital of Guizhou Medical University in China have explored the role of a long non-coding RNA (lncRNA) called ANRIL in cell proliferation and apoptosis in acute myeloid leukemia (AML) cells. Their study found that ANRIL upregulation promoted cell proliferation and inhibited apoptosis in Kasumi-1 cells by activating the PI3K/AKT/BCL-2 pathway. The research suggests that the GRK2 protein mediates the effects of ANRIL on cell behavior. This study provides new insights into the molecular mechanisms underlying apoptosis regulation in AML cells. [Extracted from the article]
Databáze:	Complementary Index
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