| Abstrakt: |
Background: Rasa Sindura (RS) is an Ayurvedic medicine that has been used for centuries to treat chronic ailments. It is composed of processed mercury and sulfur, which are known to be toxic elements, raising potential safety concerns regarding the therapeutic use of RS. Recent studies have reported the effects of RS in chronic diseases on experimental animals. However, there is still a knowledge gap in terms of its safety and toxicity. This scoping review aims to explore the existing evidence on the safety of RS and identify areas for future research to establish its safety. Methods: A systematic search was conducted on six electronic databases for relevant peer-reviewed studies. The eligibility of the article was assessed by using a set of four pre-determined criteria. From the eligible studies, we extracted and evaluated the data for quality and documented the findings using PRISMA-ScR guidelines. Results: A total of five articles were included in the scoping review in the final data extraction, synthesis, and to prepare a narrative summary. Among these articles, four studies were conducted in IIT Mumbai, and one was from Gujarat Ayurved University, Jamnagar. The studies conducted on zebrafish, zebrafish embryo, and Wistar albino rats of both sexes indicate that RS is safe up to 5TED. Conclusion: Although RS has mercury as a component, it has been reported to be safe when given at therapeutic doses to experimental animals. However, in order to establish the safety of RS, more studies are needed to examine its acute, subacute, and chronic toxicity in higher mammals. In this scoping review, only five peer-reviewed articles were identified, indicating a need for more research publications to synthesize evidence and determine the safety of drugs containing mercury. [ABSTRACT FROM AUTHOR] |
Full text from SpringerLink