| Autor: |
Sharma, Rajesh Kumar, Kumar, Sachin, Rajput, Rekha Tarasingh, Mudduluru, Niranjan Babu, Singh, Jaskirat, Gupta, Manish, Tahir, Abu, Gujar, Pooja Pradeep |
| Předmět: |
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| Zdroj: |
Biochemical & Cellular Archives; Oct2024, Vol. 24 Issue 2, p3047-3056, 10p |
| Abstrakt: |
The study aimed to formulate and evaluate an ointment incorporating Agave americana and Aloe vera extracts, known for their medicinal properties, particularly in skin care and wound healing. Preformulation studies, including purity analysis via Fourier Transform Infrared Spectroscopy (FTIR), confirmed the identity and compatibility of the herbal components. Qualitative phytochemical tests identified the presence of alkaloids, glycosides, phenolic compounds, flavonoids and saponins in the extracts. Ointments were prepared using various concentrations of Agave americana and Aloe vera with standard excipients. The physical properties of the ointments, such as spreadability, viscosity, homogeneity, and pH were assessed, demonstrating suitable consistency for topical application. The optimized ointment formulation exhibited a pH of 6.2, excellent spreadability (7.5 g.cm/sec) and high entrapment efficiency (84.5%). In vitro drug release studies demonstrated a sustained release of 78% over 24 hours, indicating a prolonged therapeutic effect. This research supports the potential of Agave americana and Aloe vera as effective components in herbal-based topical formulations for skin treatment. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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