| Autor: |
Kiruthika, M., Roy, Samyadip Singha, Srivastav, Yash, Dutta, Arpan, Reka, S., Kujur, Adeep, Prasad, Shilpi, Rai, Neeta, Kumar, Anil |
| Předmět: |
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| Zdroj: |
Biochemical & Cellular Archives; Oct2024, Vol. 24 Issue 2, p2817-2827, 11p |
| Abstrakt: |
The rise of antimicrobial resistance presents a critical challenge in modern healthcare, demanding the development of innovative therapeutic agents. Metal-based antibiotics, or metalloantibiotics, have gained attention due to their enhanced biological efficacy. Schiff base metal ion complexes, a subset of metalloantibiotics have demonstrated promising antibacterial, antifungal, antiviral, and anticancer properties. This study aims to synthesize and characterize novel Schiff base metal ion derivatives to contribute to the development of next-generation antimicrobial agents. Novel Schiff base metal ion derivatives were synthesized via the condensation of aldehydes and primary amines, followed by complexation with transition metal ions. The resulting metal complexes were characterized using Fourier-transform infrared (FTIR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy. FTIR was used to confirm the formation of the imine group (-CH=N) and metal-ligand coordination. NMR spectroscopy provided insights into the electronic environment of the protons and carbons within the complexes. FTIR spectra confirmed the successful formation of the Schiff base complexes, indicated by the presence of characteristic imine (-CH=N) peaks and metal-ligand interactions. NMR analysis revealed shifts in chemical signals consistent with metal coordination. Biological assays indicated that the synthesized metal ion derivatives exhibited enhanced antibacterial activity compared to the unmodified Schiff base ligands, with significant inhibition zones observed against common bacterial strains. In conclusion, this research provides valuable insights into the synthesis and characterization of Schiff base metal ion derivatives. The enhanced antimicrobial activity observed in the synthesized complexes supports their potential as next-generation agents to combat bacterial resistance, offering new possibilities for drug discovery and development in medicinal chemistry. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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