| Autor: |
Tiwari, Ritesh, Jain, Ritu, Patidar, Dindayal, Rajpoot, Dharmendra Singh, Shukla, Ajay Kumar |
| Předmět: |
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| Zdroj: |
Biochemical & Cellular Archives; Oct2024, Vol. 24 Issue 2, p1571-1586, 16p |
| Abstrakt: |
Patuletin is a flavonoid that is part of the O-methylated flavones subgroup. It has been the subject of a lot of attention lately because of its various pharmacological actions and possible medicinal uses. Patuletin is widely found in nature; numerous investigations have found it in a variety of plant sources, including feverfew (Tanacetum parthenium) and chamomile (Matricaria chamomilla). The pharmacological activities of patuletin encompass a broad spectrum, including anti-inflammatory, antioxidant, anti-cancer and neuroprotective effects. The anti-inflammatory properties of patuletin have been attributed to its ability to modulate key inflammatory pathways, making it a promising candidate for the development of anti-inflammatory drugs. The anti-cancer properties of patuletin have been explored in various preclinical studies, demonstrating its ability to inhibit cell proliferation, induce apoptosis and interfere with key signaling pathways involved in carcinogenesis. These findings underscore the potential of patuletin as a therapeutic agent in the field of oncology. Furthermore, emerging evidence suggests neuroprotective effects of patuletin, implicating its possible utility in the prevention or treatment of neurodegenerative disorders. The compound's interaction with neuroinflammatory processes and modulation of oxidative stress pathways present promising avenues for further investigation. This review consolidates the current knowledge on patuletin, shedding light on its multifaceted bioactive properties and potential therapeutic applications. Further research is warranted to elucidate the underlying molecular mechanisms and to assess the translational potential of patuletin in clinical settings. The diverse pharmacological activities of patuletin make it an intriguing subject for continued exploration, holding promise for the development of novel therapeutic interventions across various medical domains. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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