| Autor: |
Kiran, N. R., Settu, Vijay, Gunashekhar, H., Manjunath, B., Prem, S. Manju, Karthik, R., Jayaram, Harishkumar, G. N., Damodhara |
| Předmět: |
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| Zdroj: |
Biochemical & Cellular Archives; Oct2024, Vol. 24 Issue 2, p1547-1556, 10p |
| Abstrakt: |
Mulberry (family Moraceae) has been historically used in traditional and modern medicine. This review explores the bioactive compounds in mulberry roots, their chemical composition, biological activities, traditional uses and modern applications. Mulberry roots contain phytochemicals with significant therapeutic potential, including antioxidant, antiinflammatory, antidiabetic and antitumor effects. Mulberry root extracts, rich in compounds like morusin, kuwanon C and sanggenons, exhibit potent anti-inflammatory properties by inhibiting inflammatory mediators and modulating immune responses. These extracts also possess strong antioxidative effects due to compounds such as morusin and oxyresveratrol, which neutralize reactive oxygen species and protect cells from oxidative stress. The antidiabetic properties are attributed to bioactive compounds that regulate blood glucose levels and enhance insulin sensitivity. Studies indicate that these extracts lower blood glucose, improve insulin production and protect pancreatic b cells. Additionally, mulberry root extracts demonstrate antitumor activities by inducing apoptosis and inhibiting cell proliferation in various cancer cell lines. Compounds like sanggenol M and mulberrofurans have shown cytotoxic effects against leukemia, melanoma and colorectal cancer cells. The anti-dopaminergic effects of these extracts make them potential candidates for managing psychotic disorders, as they reduce aggression, enhance catalepsy and decrease stereotyped behavior in animal models. Recent research highlights the potential of mulberry root extracts in developing pharmaceuticals and nutraceuticals for metabolic health and chronic disease prevention. Future research should focus on clinical trials to validate their efficacy and safety in humans, bioavailability studies for optimizing therapeutic use, and mechanistic studies to elucidate molecular pathways. Standardization and quality control measures are essential for ensuring consistency and regulatory approval. In conclusion, mulberry roots are a valuable source of bioactive phytochemicals with diverse health benefits. Integrating traditional knowledge with contemporary scientific research can enhance the therapeutic applications of mulberry roots in modern medicine. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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