| Autor: |
Abdulhamed, Abdulrahman A., Khaleel, Luma W. |
| Předmět: |
|
| Zdroj: |
Pharmakeftiki; Jul-Sep2024, Vol. 36 Issue 3, p67-82, 16p |
| Abstrakt: |
Objective: To study the antidiabetic effect of Glycyrrhiza glabra ethanolic extract and Glycyrrhiza glabra silver nanoparticle against induced diabetes mellitus (DM) by alloxan and nicotinamide in adult female Rats. Methods: The current study was performed over 36 days in which the G. glabra extract (200 mg/ Kg) and G. glabra extract loaded on Silver nanoparticle (230 μ g/ Kg) were given to alloxan and nicotinamide (120mg/kg, 50 mg/kg, respectively, single dose, IP) induced diabetic rats (10 rats per group). The antidiabetic effect has been evaluated biochemically. Results: The results of induction of DM for 36 days showed a significant increase (P<0.05) in serum Glucose concentration with a significant decrease (P<0.05) in serum insulin concentration in DM induced (G2) group when compared with the control group (G1). and showed a significant decrease (P<0.05) in the serum glucose concentration and a significant increase (P<0.05) of serum insulin concentration in (G3) group (received G. glabra extract) and (G4) group (G.glabra loaded on silver nanoparticle) in comparison with G2. Conclusion: This study concluded that Glycyrriza glabra extract and Glycyrrhiza glabra Silver nanoparticle have a significant antidiabetic effect induced by alloxan and nicotinamide. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
