| Autor: |
Soni, Shruti, Maheshwari, R. K., Sah, Abhishek K. |
| Zdroj: |
BioNanoScience; Nov2024, Vol. 14 Issue 4, p3988-4005, 18p |
| Abstrakt: |
For the delivery of the drug, the oral route is the most preferable due to ease of administration. However, the effective delivery of poorly aqueous soluble drugs is very challenging for the pharmaceutical scientist which leads to a low drug permeation profile across the biological membrane, poor drug bioavailability, and ultimately low therapeutic profile with less patient comfort. The inclusion of a therapeutic agent into the nanostructured-based lipid carrier can improve the limitation associated with the poorly soluble drug and it includes better drug therapeutic, pharmacokinetic profile, and controlled drug release up to a longer duration of time which causes patient compliance. Nanostructure lipid carriers (NLCs) are nanosized-based carrier systems which comprise solid lipid matrix combined with liquid lipids and surfactants. The aim of the paper is to explore the various advantages of formulation technology along with the characterization parameter of the NLCs and also report the clinical finding of the investigated NLCs for oral drug delivery system. This paper also highlighted the various patents on the NLCs. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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