| Autor: |
Quintanilla-Bordás, Carlos, Gorriz, David, Cubas-Núñez, Laura, Castillo-Villalba, Jéssica, Carreres-Polo, Joan, Casanova, Bonaventura, Pérez-Miralles, Francisco Carlos |
| Předmět: |
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| Zdroj: |
Frontiers in Immunology; 2024, p1-4, 4p |
| Abstrakt: |
Background: We report the first case of findings suggestive of progressive multifocal leukoencephalopathy and immune restitution syndrome (PML-IRIS) in a patient with multiple sclerosis receiving ozanimod preceded by an unexpected increase in the serum neurofilament light-chain (sNfL) levels. Case report: A 57-year-old-woman treated with ozanimod for the last 8 years presented, during surveillance MRI, with findings compatible with PML-IRIS. Overt clinical symptoms were absent. sNfL levels increased 4 months earlier and peaked at presentation. Lymphocyte count reached nadir of 330/mL at 8 months earlier. Conclusion: The case illustrates the utility of sNfL levels for PML surveillance in patients receiving immunosuppressors. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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