Clinical emergence of a novel extended-spectrum variant deriving from the OXY-1 β-lactamase.

Autor:	Hong Tuan Ha, Anne-Sophie, Mammeri, Alice, Plainvert, Céline, Charfi, Rym, Poyart, Claire, Tazi, Asmaa, Mammeri, Hedi
Předmět:	CEFOTAXIME ESCHERICHIA coli CEFEPIME KLEBSIELLA CEFTAZIDIME GENETIC mutation
Zdroj:	European Journal of Clinical Microbiology & Infectious Diseases; Nov2024, Vol. 43 Issue 11, p2215-2219, 5p
Abstrakt:	The genomic comparison of two Klebsiella michiganensis clinical isolates recovered from the same patient, one resistant to piperacillin-tazobactam and intermediate to cefotaxime, the other resistant to ceftazidime but susceptible to piperacillin-tazobactam, revealed one mutation in the blaOXY-1-24 gene accounting for a L169M substitution in the Ω loop. Cloning experiment in Escherichia coli demonstrated the contribution of this mutation to the hydrolysis spectrum extension towards ceftazidime and cefepime, whereas the resistance to piperacillin-tazobactam was reduced. To the best of our knowledge, this study shows for the first time that ceftazidime resistance can occur in vivo from OXY-1 precursor by structural alteration. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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