| Autor: |
Cossarini, Francesca, Shang, Joan, Krek, Azra, Al-Taie, Zainab, Hou, Ruixue, Canales-Herrerias, Pablo, Tokuyama, Minami, Tankelevich, Michael, Tillowitz, Adam, Jha, Divya, Livanos, Alexandra E., Leyre, Louise, Uzzan, Mathieu, Martinez-Delgado, Gustavo, Taylor, Matthew D., Sharma, Keshav, Bourgonje, Arno R., Cruz, Michael, Ioannou, Giorgio, Dawson, Travis |
| Předmět: |
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| Zdroj: |
Science Immunology; 2024, Vol. 9 Issue 100, p1-19, 19p |
| Abstrakt: |
Gastrointestinal (GI) B cells and plasma cells (PCs) are critical to mucosal homeostasis and the host response to HIV-1 infection. Here, high-resolution mapping of human B cells and PCs sampled from the colon and ileum during both viremic and suppressed HIV-1 infection identified a reduction in germinal center (GC) B cells and follicular dendritic cells (FDCs) during HIV-1 viremia. Immunoglobulin A–positive (IgA+) PCs are the major cellular output of intestinal GCs and were significantly reduced during viremic HIV-1 infection. PC-associated transcriptional perturbations, including type I interferon signaling, persisted in antiretroviral therapy (ART)–treated individuals, suggesting ongoing disruption of the intestinal immune milieu during ART. GI humoral immune perturbations were associated with changes in the intestinal microbiome composition and systemic inflammation. These findings highlight a key immune defect in the GI mucosa due to HIV-1 viremia. Editor's summary: The gastrointestinal (GI) tract is a key site of HIV-1 replication because of the presence of CCR5+CD4+ T cells, but less is known about GI-associated B cell responses. Cossarini et al. undertook a detailed analysis of B cells and plasma cells (PCs) in the GI tracts of viremic and antiretroviral (ART)–suppressed people living with HIV. HIV viremia was associated with the depletion of germinal center B cells, IgA+ PCs, and follicular dendritic cells, as well as microbial dysbiosis and systemic inflammation. Despite suppression of viral replication, ART was linked to persistent transcriptional changes in PCs, including altered type I interferon responses. This study highlights the intestinal B cell responses during HIV-1 viremia, thus broadening our understanding of the major changes occurring in the GI system during infection. —Christiana N. Fogg [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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