New Findings in Liver Diseases and Conditions Described from Chungbuk National University (Blockade of 11b-hydroxysteroid dehydrogenase type 1 ameliorates metabolic dysfunction-associated steatotic liver disease and fibrosis).

Předmět:	HYDROXYSTEROID dehydrogenases DIGESTIVE system diseases HEPATIC fibrosis ALCOHOL dehydrogenase LIVER diseases CORTISONE
Zdroj:	Gastroenterology Week; 11/5/2024, p1750-1750, 1p
Abstrakt:	Researchers from Chungbuk National University in South Korea have conducted a study on the effects of inhibiting the enzyme 11b-hydroxysteroid dehydrogenase type 1 (11b-HSD1) on metabolic dysfunction-associated steatotic liver disease (MASLD) and fibrosis. The study found that the inhibitor INU-101 effectively reduced cortisol-induced lipid accumulation, oxidative stress, and liver damage in mice fed a fast-food diet. The research suggests that INU-101 could be a potential therapeutic candidate for treating MASLD and fibrosis by targeting the processes involving 11b-HSD1 and cortisol regulation in the liver. [Extracted from the article]
Databáze:	Complementary Index
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