Serum and urinary levels of tumor necrosis factor-alpha and interferon-gamma in diabetic nephropathy patients: a systematic review.

Autor:	Flake, Chastene Christopher, Aguas, Imoan Shallom, Policarpio, Archie, Ysais, Angelanna, Tiongco, Raphael Enrique, Navarro, Annalyn
Předmět:	CREATININE DIABETIC nephropathies INTERFERONS SYSTEMATIC reviews MEDLINE TYPE 2 diabetes URINALYSIS ONLINE information services ALBUMINS CYTOKINES TUMOR necrosis factors GLOMERULAR filtration rate BIOMARKERS DISEASE complications
Zdroj:	International Journal of Diabetes in Developing Countries; Dec2024, Vol. 44 Issue 4, p644-651, 8p
Abstrakt:	Objective: In this systematic review, we determined the association of selected inflammatory cytokines in blood and urine with diabetic nephropathy (DN). Methods: A literature search using the key terms "tumor necrosis factor-alpha," "interferon-gamma," and "diabetic nephropathy" was conducted in PubMed from December 2020 to January 2021. Relevant findings from these studies were collated for qualitative synthesis. Results: Based on the synthesis of results, TNF-α and IFN-γ levels were consistently higher among DN patients than T2DM patients with no renal complications and healthy individuals. A negative correlation with the estimated glomerular filtration rate (eGFR) and a positive correlation with the albumin-to-creatinine ratio (ACR) were also noted by most studies which assessed their relationship with renal markers. Conclusion: The findings of this systematic review suggest the association of serum and urinary TNF-α and IFN-γ levels with diabetic nephropathy. However, further studies must be conducted to confirm these findings. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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