Clinicopathological Implications of Serum level of IL-27 in Endometrial Cancer Patients.
| Autor: | Sedaghat, Fatemeh, Shiravani, Zahra, Karimi, Ali Mohammad, Haghshenas, Mohammad Reza, Ghaderi, Abbas, Fattahi, Mohammad Javad |
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| Předmět: |
RECEIVER operating characteristic curves
RESEARCH funding ENZYME-linked immunosorbent assay KRUSKAL-Wallis Test FISHER exact test SYMPTOMS MANN Whitney U Test CHI-squared test CANCER patients ENDOMETRIAL tumors CASE-control method COMPARATIVE studies DATA analysis software INTERLEUKINS SENSITIVITY & specificity (Statistics) |
| Zdroj: | Journal of Obstetrics, Gynecology & Cancer Research; Nov/Dec2024, Vol. 9 Issue 6, p658-666, 9p |
| Abstrakt: | Background & Objective: Endometrial cancer (EC) is the most prevalent gynecological malignancy in more developed countries. Multiple researches have been done about the role of IL-27 in different cancers that suggest a dual role for this cytokine. In the present study, we evaluated the serum level of IL-27 in endometrial cancer patients. We also investigated the correlations between serum levels of IL-27 and the demographic and clinicopathologic features of the patients. Materials & Methods: In this case-control study, 65 endometrial cancer patients and 58 sex-age-match healthy controls were investigated. Serum levels of IL-27 in both cases and the control group were assessed by a reliable and specific sandwich enzymelinked immunosorbent assay (ELISA) kit and results were analyzed with SPSS. Results: We observed that the serum level of IL-27 in EC patients was dramatically higher than in the control group (P=0.003). Additionally, Higher grades of EC (grade II and III) showed higher IL-27 serum levels compared to the control (P=0.006 and P=0.01 respectively). No significant correlations between serum levels of IL-27 and lymph node involvement, tumor stage, tumor size, and demographic features of the patients were detected. Conclusion: Our results showed that there is a statistically significant difference between serum levels of IL-27 in EC patients and controls. Therefore, the serum level of IL-27 may exert a role in the pathogenesis of endometrial carcinoma, although further studies are needed. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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