Low 25-Hydroxyvitamin D [25(OH)D] Levels as a Predictor of Depressive Symptoms: Evidence from Community-Dwelling Older Adults Population in Mexico City.

Autor: Llanos-Becerra, Graciela, Dávila-Godínez, Eduardo, Torres-Carrillo, Norma, Rosas-Carrasco, Oscar, Sandoval-Pinto, Elena, Beltrán-Ramírez, Raúl, Torres-Carrillo, Nora Magdalena
Předmět:
Zdroj: Experimental Aging Research; Oct-Dec2024, Vol. 50 Issue 5, p742-752, 11p
Abstrakt: Objective: The purpose of this study was to assess the association between serum 25-hydroxyvitamin D [25(OH)D] levels and depressive symptoms in Mexican older adults 70 years and older. Methods: A total of 326 adults aged 70 or older from Coyoacán Cohort Study were included in this study. The depressive symptoms were assessing by Center for Epidemiologic Studies Depression Scale (CES-D) and serum 25-hydroxyvitamin D [25(OH)D] levels were measured by commercially available enzyme-linked immunosorbent assay (ELISA). Results: Overall, the prevalence of depressive symptoms was 36.5%. The mean age was 79 years, and 53.4% were women. The total serum 25-hydroxyvitamin D [25(OH)D] levels were lower in older adults with depressive symptoms when compared with older adults without depressive symptoms (p =.006). Logistic regression models showed a significant association between low serum 25(OH)D levels and depressive symptoms even after adjusting for potential confounders (OR = 2.453; 95% CI:1.218–4.939; p =.012). In addition, linear regression model to predict the effect of 25-hydroxyvitamin D [25(OH)D] levels on the CES-D score as a continuous variable, was statistically significant [F(1,324) = 8.54, p =.004], and the R-squared value was.026, indicating that this regression model explains 2.6% of the change in the CES-D score. Conclusion: These results suggest that older Mexican adults with lower serum 25-hydroxyvitamin D [25(OH)D] levels are at higher risk of presenting depressive symptoms. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
Externí odkaz: