| Autor: |
Hipol, Regina Lourdes B., Wayas, Hilda S., Bacuyag, Florence Mae S., Cabanlong, Jedida F., Daquigan, Madonna C., Hipol, Roland M. |
| Předmět: |
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| Zdroj: |
Indonesian Journal of Pharmacy / Majalah Farmasi Indonesia; Jul-Sep2024, Vol. 35 Issue 3, p409-424, 16p |
| Abstrakt: |
Acalypha is a valuable genus that has interesting pharmaceutical applications. This study investigated the phytochemical composition and thin layer chromatography (TLC) profile, as well as the antioxidant and antibacterial activities of the ethanolic leaf extract of Acalypha angatensis Blanco, Fl. Filip. Qualitative phytochemical screening revealed the presence of tannins, phenolics, flavonoids, saponins, steroids, and triterpenoids. Nutrient analysis showed that potassium and calcium contents were at 1.499 g/100g and 1.38 g/100g, respectively. The determination of the total phenolic content (TPC) showed that this species has an average of 282.24 ± 3.56 mg GAE/g and a total flavonoid content (TFC) of 36.24 ± 3.77 mg QE/g of dried extract. These values are higher than other Acalypha species that have already been studied. Antioxidant activity, measured using the DPPH antioxidant assay, showed a concentration-dependent radical scavenging effect, with an IC50 of 34.02 µg/mL. The ethanolic extract exhibited substantial antibacterial activity against the gram-positive bacteria, Enterococcus faecium (NCTC 12204) and MRSA (ATCC 33592), with a minimum inhibitory concentration (MIC) of 4 mg/mL. Higher concentrations (>20 mg/mL) were needed for inhibition of the gram-negative strains (Klebsiella pneumoniae and Enterobacter cloacae). These results suggest that A. angatensis has good antioxidant and antibacterial activities against gram positive bacteria, supporting its use in traditional medicine. This species has the potential to be a raw material for pharmaceutical and nutraceutical products. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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