| Autor: |
Hidekazu Hasunuma, Tomoko Ishida, Hiroki Otaki, Youichi Iwashita, Tamotsu Machida, Sanshiro Nakao, Mizuki Nonaka, Sayaka Suzuki, Akiko Takashima, Yasuhiro Kawase, Naomi Shimizu |
| Předmět: |
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| Zdroj: |
Japanese Journal of Transfusion & Cell Therapy / Nihon Yuketsu Saibo Chiryo Gakkaishi; 2024, Vol. 70 Issue 4, p502-508, 7p |
| Abstrakt: |
We experienced a case of hemolytic anemia in a baby at late onset from a pregnant woman with anti-E titer, 128 times. Red blood cell (RBC) transfusion performed on day 11 after birth resulted in an improvement in hemoglobin, but anemia recurred 51 days later. We measured the IgG subclass and conducted a Monocyte Monolayer Assay (MMA) over time, and then analyzed the association of the condition of the mother and the child's RBC ratio post-transfusion. Anti-E of the mother and the baby were of the IgG1 type, and MMA rates were low in both. The delayed progression and recurrence of hemolysis in this case were due to the low MMA, resulting from the anti-E derived from IgG1 type, and because the remaining anti-E reacted with the baby's RBCs that were regenerated after transfusion. Neonatal hemolytic disease caused by anti-E, high-titer IgG1 requires long-term follow-up. Analysis of IgG subclasses of irregular antibodies in pregnant women may help predict the pathology of Hemolytic Disease of the Fetus and Newborn (HDFN). [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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