| Abstrakt: |
Simple Summary: This study investigates the health benefits of Clinacanthus nutans extracts, specifically the 95% ethanol extract and its nanoemulsified form, highlighting their potential for oral health and diabetes management. These extracts exhibit strong antibacterial activity against harmful oral bacteria, including Streptococcus mutans and Staphylococcus aureus, which are important for preventing periodontal diseases. They also possess significant anti-biofilm properties, which help reduce dental plaque formation. In addition, the extracts inhibit the enzyme α-glucosidase, suggesting they may aid in regulating blood sugar levels in diabetes. Their anti-inflammatory effects, demonstrated by reduced nitric oxide production, indicate potential benefits for treating oral infections and inflammation. Nanoemulsification enhances the extracts' solubility, stability, and bioavailability, improving their therapeutic effectiveness. Overall, this study suggests that Clinacanthus nutans extracts, particularly in nanoemulsified form, could be developed into new treatments for oral health issues and metabolic disorders such as diabetes. Further research is needed to confirm their safety and effectiveness in clinical applications. This study investigates the therapeutic potential of Clinacanthus nutans extracts, focusing on the 95% ethanol (95E) extract and its nanoemulsified form, against oral pathogens and their bioactive effects. The findings demonstrate potent antibacterial activity against Streptococcus mutans and Staphylococcus aureus, essential for combating periodontal diseases, and significant anti-biofilm properties crucial for plaque management. Additionally, the extracts exhibit promising inhibitory effects on α-glucosidase enzymes, indicating potential for diabetes management through glucose metabolism regulation. Their anti-inflammatory properties, evidenced by reduced nitric oxide production, underscore their potential for treating oral infections and inflammation. Notably, the nanoemulsified 95E extract shows higher efficiency than the conventional extract, suggesting a multifunctional treatment approach for periodontal issues and metabolic disorders. These results highlight the enhanced efficacy of the nanoemulsified extract, proposing it as an effective treatment modality for periodontal disease in diabetic patients. This research offers valuable insights into the development of innovative drug delivery systems using natural remedies for improved periodontal care in diabetic populations. [ABSTRACT FROM AUTHOR] |
