A New Tool for Extracting Static and Dynamic Parameters from [ 18 F]F-DOPA PET/CT in Pediatric Gliomas.

Autor: Mureddu, Michele, Funck, Thomas, Morana, Giovanni, Rossi, Andrea, Ramaglia, Antonia, Milanaccio, Claudia, Verrico, Antonio, Bottoni, Gianluca, Fiz, Francesco, Piccardo, Arnoldo, Fato, Marco Massimo, Trò, Rosella
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Zdroj: Journal of Clinical Medicine; Oct2024, Vol. 13 Issue 20, p6252, 16p
Abstrakt: Background/Objectives: PET imaging with [18F]F-DOPA has demonstrated high potential for the evaluation and management of pediatric brain gliomas. Manual extraction of PET parameters is time-consuming, lacks reproducibility, and varies with operator experience. Methods: In this study, we tested whether a semi-automated image processing framework could overcome these limitations. Pediatric patients with available static and/or dynamic [18F]F-DOPA PET studies were evaluated retrospectively. We developed a Python software to automate clinical index calculations, including preprocessing to delineate tumor volumes from structural MRI, accounting for lesions with low [18F]F-DOPA uptake. A total of 73 subjects with treatment-naïve low- and high-grade gliomas, who underwent brain MRI within two weeks of [18F]F-DOPA PET, were included and analyzed. Static analysis was conducted on all subjects, while dynamic analysis was performed on 32 patients. Results: For 68 subjects, the Intraclass Correlation Coefficient for T/S between manual and ground truth segmentation was 0.91. Using our tool, ICC improved to 0.94. Our method demonstrated good reproducibility in extracting static tumor-to-striatum ratio (p = 0.357); however, significant differences were observed in tumor slope (p < 0.05). No significant differences were found in time-to-peak (p = 0.167) and striatum slope (p = 0.36). Conclusions: Our framework aids in analyzing [18F]F-DOPA PET images of pediatric brain tumors by automating clinical score extraction, simplifying segmentation and Time Activity Curve extraction, reducing user variability, and enhancing reproducibility. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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