| Autor: |
Gao, Qiansong, Wang, Mingchun, Zheng, Lianyou, Shi, Lingling, Wu, Cheng, Li, He, Xiang, Jinbao |
| Předmět: |
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| Zdroj: |
Green Chemistry; 11/7/2024, Vol. 26 Issue 21, p10975-10981, 7p |
| Abstrakt: |
Deuterium-labeled molecules play a crucial role in numerous areas, from medicinal chemistry to chemical biology, providing a unique opportunity to improve ADMET properties and study the biological fate of bioactive molecules. Herein, we present an electromigratory reductive deuteration of terminal alkynes to access a diverse array of enamides with more than 3 deuteriums incorporated per molecule, using CD3CN as a deuterium source. The reaction proceeds under mild neutral conditions, does not require precious transition metals, and shows broad substrate scope with excellent E-selectivity. We envision that this on-demand high deuterium incorporation will provide considerable opportunities in therapeutics and biological research. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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