| Autor: |
Yuan, Yong, Jiang, Hangfei, Zhang, Ya-Nan, Tao, Yuyan, Liu, Xincong, Huo, Congde |
| Předmět: |
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| Zdroj: |
Green Chemistry; 11/7/2024, Vol. 26 Issue 21, p10811-10817, 7p |
| Abstrakt: |
An electroreductive deoxygenative carboxylation of alkyl oxalates with CO2 is demonstrated for the first time, which offers a general and scalable method for obtaining various carboxylic acids. This electrochemical method features a broad substrate scope and mild reaction conditions; various secondary benzyl alcohols and non-benzylic alcohols, primary benzyl alcohols and non-benzylic alcohols, and tertiary benzyl alcohols and non-benzylic alcohols can be converted into the corresponding carboxylic acids in good to excellent yields. Importantly, this electroreductive deoxygenative carboxylation reaction also offers a mild and straightforward route to access drug molecules, such as ibuprofen, (±) naproxen, fenoprofen, hexaprofen, and biprofen. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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