Association of vascular endothelial growth factor‐C, plasma angiotensinogen and left ventricular hypertrophy in patients with hemodialysis.

Autor: Yeter, Haci Hasan, Levent, Mustafa, Sahiner, Levent, Yildirim, Tolga, Yilmaz, Rahmi
Předmět:
Zdroj: Therapeutic Apheresis & Dialysis; Dec2024, Vol. 28 Issue 6, p904-911, 8p
Abstrakt: Introduction: This study aims to examine the relationship between fluid overload, Vascular Endothelial Growth Factor C (VEGF‐C), plasma Angiotensinogen (pAGT), and echocardiography findings in hemodialysis patients. Methods: This was a single‐center, cross‐sectional study. Patients were divided into two groups according to mid‐week inter‐dialytic weight gain (mIDWG): (1) mIDWG ≤3% and (2) mIDW >3%. Results: A total of 55 patients were enrolled in this study. While the mean pAGT and left ventricular mass index were significantly higher in patients with mIDWG >3% compared to patients with mIDWG ≤3%, VEGF‐C was similar between groups. pAGT ≥76.8 mcg/L, VEGF‐C ≤175.5 pg/ML, and pAGT /VEGF‐C ≥0.45 were significant cut‐offs for the prediction of left ventricular hypertrophy(LVH). Univariate logistic regression analysis revealed that these cut‐off values were significantly associated with LVH. Conclusion: Renin‐angiotensin‐aldosterone system activation may persist in hemodialysis patients with excessive IDWG. Additionally, pAGT and VEGF‐C could be risk factors for the development of LVH. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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