Synthesis and anti-inflammatory activity of N-substituted 4-aryl-2-[(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)amino]-4-oxobut-2-enamides.

Autor:	Gorbunova, I. A., Okoneshnikova, E. A., Makhmudov, R. R., Shadrin, V. M., Silaichev, P. S., Shipilovskikh, S. A., Shipilovskikh, D. A.
Předmět:	CHEMICAL synthesis ANTI-inflammatory agents DRUG toxicity IN vivo studies THIOPHENES
Zdroj:	Russian Chemical Bulletin; Sep2024, Vol. 73 Issue 9, p2758-2764, 7p
Abstrakt:	Synthesis of N-substituted 4-aryl-2-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-ylamino)-4-oxobut-2-enamides by the reaction of the substituted 2-[(5-aryl-2-oxofuran-3(2H)-ylidene)amino]-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitriles with primary amines was developed. Anti-inflammatory activity and acute toxicity of the synthesized compounds were examined. It was found that the synthesized compounds possess pronounced anti-inflammatory activity and low toxicity. According to the classification of toxicity of drugs, the synthesized amides belong to toxicity class V of practically nontoxic substances. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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