| Autor: |
Krijnen, Eva A, Kouwenhoven, Rose-Marie, Noteboom, Samantha, Barkhof, Frederik, Uitdehaag, Bernard MJ, Klawiter, Eric C, Steenwijk, Martijn D, Schoonheim, Menno M, Koubiyr, Ismail |
| Předmět: |
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| Zdroj: |
Multiple Sclerosis Journal; Oct2024, Vol. 30 Issue 11/12, p1556-1560, 5p |
| Abstrakt: |
Background: Cortical lesion subtypes' occurrence and distribution across networks may shed light on cognitive impairment (CI) in multiple sclerosis (MS). Methods: In 332 people with MS, lesions were classified as intracortical, leukocortical or juxtacortical based on artificially generated double inversion-recovery images. Results: CI-related leukocortical lesion count increases were greatest within sensorimotor and cognitive networks (p < 0.001). Only intracortical lesion count could distinguish between cognitive groups (p = 0.024). Effect sizes were two- to four-fold larger than differences between MS phenotypes. Conclusion: In CI-MS, leukocortical lesions predominate, whereas intracortical lesions distinguish cognitive groups. Lesions' grey matter (GM) involvement might be decisive for cognition in MS, surpassing overall disease burden. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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